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Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes highly racemizable 3,5-dihydroxyphenylglycines (Dpgs). Here we describe the total synthesis of feglymycin based on a linear/convergent hybrid approach. Our originally developed micro-flow amide bond formatio...

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Publié dans:Nat Commun
Auteurs principaux: Fuse, Shinichiro, Mifune, Yuto, Nakamura, Hiroyuki, Tanaka, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133696/
https://ncbi.nlm.nih.gov/pubmed/27892469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13491
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