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Convergent Total Synthesis of Yaku’amide A
Total synthesis of the anticancer peptide natural product yaku’amide A is reported. Its β-tert hydroxy amino acids were prepared via regioselective aminohydroxylation involving a chiral mesyloxycarbamate reagent. Stereospecific construction of the E- and Z-ΔIle residues was accomplished via a one-po...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902439/ https://ncbi.nlm.nih.gov/pubmed/33336547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014238 |
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