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Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor**

The development of highly efficient amide bond forming methods which are devoid of side reactions, including epimerization, is important, and such a method is described herein and is based on the concept of rapid and strong activation of carboxylic acids. Various carboxylic acids are rapidly (0.5 s)...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Fuse, Shinichiro, Mifune, Yuto, Takahashi, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499250/
https://ncbi.nlm.nih.gov/pubmed/24402801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307987
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