Evaluation of the Effect of Tofacitinib on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Volunteers

Tofacitinib is an oral Janus kinase inhibitor. Tofacitinib metabolism is primarily mediated by cytochrome P450 3A4. This phase 1 randomized, open‐label, 2‐way crossover study (NCT01137708) evaluated the effect of tofacitinib 30 mg twice daily on the single‐dose pharmacokinetics of combination oral c...

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Publicado en:Clin Pharmacol Drug Dev
Autores principales: Menon, Sujatha, Riese, Richard, Wang, Ronnie, Alvey, Christine W., Shi, Haihong, Petit, Wendy, Krishnaswami, Sriram
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132016/
https://ncbi.nlm.nih.gov/pubmed/27138968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.270
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