Evaluation of the Effect of Tofacitinib on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Volunteers

Tofacitinib is an oral Janus kinase inhibitor. Tofacitinib metabolism is primarily mediated by cytochrome P450 3A4. This phase 1 randomized, open‐label, 2‐way crossover study (NCT01137708) evaluated the effect of tofacitinib 30 mg twice daily on the single‐dose pharmacokinetics of combination oral c...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Drug Dev
Main Authors: Menon, Sujatha, Riese, Richard, Wang, Ronnie, Alvey, Christine W., Shi, Haihong, Petit, Wendy, Krishnaswami, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132016/
https://ncbi.nlm.nih.gov/pubmed/27138968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.270
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