ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

The interferon-inducible protein Z-DNA binding protein 1 (ZBP1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) was identified as a dsDNA sensor, which instigates innate immune responses. However, this classification has been disputed and whether ZBP1 functions as a...

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Bibliographic Details
Published in:Sci Immunol
Main Authors: Kuriakose, Teneema, Man, Si Ming, Malireddi, R.K. Subbarao, Karki, Rajendra, Kesavardhana, Sannula, Place, David E., Neale, Geoffrey, Vogel, Peter, Kanneganti, Thirumala-Devi
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131924/
https://ncbi.nlm.nih.gov/pubmed/27917412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aag2045
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