ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

Innate sensing of influenza virus infection induces activation of programmed cell death pathways. We have recently identified Z-DNA–binding protein 1 (ZBP1) as an innate sensor of influenza A virus (IAV). ZBP1-mediated IAV sensing is critical for triggering programmed cell death in the infected lung...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kesavardhana, Sannula, Kuriakose, Teneema, Guy, Clifford S., Samir, Parimal, Malireddi, R.K. Subbarao, Mishra, Ashutosh, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551577/
https://ncbi.nlm.nih.gov/pubmed/28634194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170550
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