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Genome-Editing Technologies: Principles and Applications

Targeted nucleases have provided researchers with the ability to manipulate virtually any genomic sequence, enabling the facile creation of isogenic cell lines and animal models for the study of human disease, and promoting exciting new possibilities for human gene therapy. Here we review three foun...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Biol
Main Authors: Gaj, Thomas, Sirk, Shannon J., Shui, Sai-lan, Liu, Jia
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131771/
https://ncbi.nlm.nih.gov/pubmed/27908936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a023754
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