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TALENs: a widely applicable technology for targeted genome editing

Engineered nucleases enable the targeted alteration of any DNA sequence in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a non-specific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered...

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Detalhes bibliográficos
Main Authors: Joung, J. Keith, Sander, Jeffry D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547402/
https://ncbi.nlm.nih.gov/pubmed/23169466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3486
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