Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

Inhibition of the mechanistic target of rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with the intracellular immunophilin FKBP12, a prolyl isomerase with different cellul...

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Udgivet i:Oncotarget
Main Authors: Raimondo, Lucia, D'Amato, Valentina, Servetto, Alberto, Rosa, Roberta, Marciano, Roberta, Formisano, Luigi, Mauro, Concetta Di, Orsini, Roberta Clara, Cascetta, Priscilla, Ciciola, Paola, De Maio, Ana Paula, Di Renzo, Maria Flavia, Cosconati, Sandro, Bruno, Agostino, Randazzo, Antonio, Napolitano, Filomena, Montuori, Nunzia, Veneziani, Bianca Maria, Placido, Sabino De, Bianco, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129993/
https://ncbi.nlm.nih.gov/pubmed/27223077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9484
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