Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors

The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. Its expression is increased in many human cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), and co...

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Published in:Sci Rep
Main Authors: Mauro, Concetta Di, Pesapane, Ada, Formisano, Luigi, Rosa, Roberta, D’Amato, Valentina, Ciciola, Paola, Servetto, Alberto, Marciano, Roberta, Orsini, Roberta Clara, Monteleone, Francesca, Zambrano, Nicola, Fontanini, Gabriella, Servadio, Adele, Pignataro, Giuseppe, Grumetto, Lucia, Lavecchia, Antonio, Bruzzese, Dario, Iaccarino, Antonino, Troncone, Giancarlo, Veneziani, Bianca Maria, Montuori, Nunzia, Placido, Sabino De, Bianco, Roberto
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571185/
https://ncbi.nlm.nih.gov/pubmed/28839232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10062-1
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