Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Lachmandas, Ekta, Beigier‐Bompadre, Macarena, Cheng, Shih‐Chin, Kumar, Vinod, van Laarhoven, Arjan, Wang, Xinhui, Ammerdorffer, Anne, Boutens, Lily, de Jong, Dirk, Kanneganti, Thirumala‐Devi, Gresnigt, Mark S., Ottenhoff, Tom H.M., Joosten, Leo A.B., Stienstra, Rinke, Wijmenga, Cisca, Kaufmann, Stefan H.E., van Crevel, Reinout, Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Immunity to infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129526/
https://ncbi.nlm.nih.gov/pubmed/27624090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546259
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