Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host...

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Библиографические подробности
Опубликовано в: :Eur J Immunol
Главные авторы: Lachmandas, Ekta, Beigier‐Bompadre, Macarena, Cheng, Shih‐Chin, Kumar, Vinod, van Laarhoven, Arjan, Wang, Xinhui, Ammerdorffer, Anne, Boutens, Lily, de Jong, Dirk, Kanneganti, Thirumala‐Devi, Gresnigt, Mark S., Ottenhoff, Tom H.M., Joosten, Leo A.B., Stienstra, Rinke, Wijmenga, Cisca, Kaufmann, Stefan H.E., van Crevel, Reinout, Netea, Mihai G.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Immunity to infection
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129526/
https://ncbi.nlm.nih.gov/pubmed/27624090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546259
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