Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress

The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control energy metabolism in peripheral tissues. Mice lacking the kappa opioid receptor (κ...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Imbernon, Monica, Sanchez‐Rebordelo, Estrella, Romero‐Picó, Amparo, Kalló, Imre, Chee, Melissa J., Porteiro, Begoña, Al‐Massadi, Omar, Contreras, Cristina, Fernø, Johan, Senra, Ana, Gallego, Rosalia, Folgueira, Cintia, Seoane, Luisa M., van Gestel, Margriet, Adan, Roger A., Liposits, Zsolt, Dieguez, Carlos, López, Miguel, Nogueiras, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Steatohepatitis/Metabolic Liver Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129461/
https://ncbi.nlm.nih.gov/pubmed/27387967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28716
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