MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Melanin-concentrating hormone (MCH) is an important regulator of food intake, glucose metabolism, and adiposity. However, the mechanisms mediating these actions remain largely unknown. We used pharmacological and genetic approaches to show that the sirtuin 1 (SIRT1)/FoxO1 signaling pathway in the hy...

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Vydáno v:Diabetes
Hlavní autoři: Al-Massadi, Omar, Quiñones, Mar, Clasadonte, Jerome, Hernandez-Bautista, René, Romero-Picó, Amparo, Folgueira, Cintia, Morgan, Donald A., Kalló, Imre, Heras, Violeta, Senra, Ana, Funderburk, Samuel C., Krashes, Michael J., Souto, Yara, Fidalgo, Miguel, Luquet, Serge, Chee, Melissa J., Imbernon, Monica, Beiroa, Daniel, García-Caballero, Lucía, Gallego, Rosalia, Lam, Brian Y.H., Yeo, Giles, Lopez, Miguel, Liposits, Zsolt, Rahmouni, Kamal, Prevot, Vincent, Dieguez, Carlos, Nogueiras, Ruben
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2019
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868473/
https://ncbi.nlm.nih.gov/pubmed/31530579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0029
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