MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Melanin-concentrating hormone (MCH) is an important regulator of food intake, glucose metabolism, and adiposity. However, the mechanisms mediating these actions remain largely unknown. We used pharmacological and genetic approaches to show that the sirtuin 1 (SIRT1)/FoxO1 signaling pathway in the hy...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Al-Massadi, Omar, Quiñones, Mar, Clasadonte, Jerome, Hernandez-Bautista, René, Romero-Picó, Amparo, Folgueira, Cintia, Morgan, Donald A., Kalló, Imre, Heras, Violeta, Senra, Ana, Funderburk, Samuel C., Krashes, Michael J., Souto, Yara, Fidalgo, Miguel, Luquet, Serge, Chee, Melissa J., Imbernon, Monica, Beiroa, Daniel, García-Caballero, Lucía, Gallego, Rosalia, Lam, Brian Y.H., Yeo, Giles, Lopez, Miguel, Liposits, Zsolt, Rahmouni, Kamal, Prevot, Vincent, Dieguez, Carlos, Nogueiras, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868473/
https://ncbi.nlm.nih.gov/pubmed/31530579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0029
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