Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation

The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine and clozapine. However, the molecular mechanisms involved in antipsychotic-i...

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Detalhes bibliográficos
Main Authors: Fernø, Johan, Varela, Luis, Skrede, Silje, Vázquez, María Jesús, Nogueiras, Rubén, Diéguez, Carlos, Vidal-Puig, Antonio, Steen, Vidar M., López, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113797/
https://ncbi.nlm.nih.gov/pubmed/21695181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020571
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