Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation

The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine and clozapine. However, the molecular mechanisms involved in antipsychotic-i...

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Autors principals: Fernø, Johan, Varela, Luis, Skrede, Silje, Vázquez, María Jesús, Nogueiras, Rubén, Diéguez, Carlos, Vidal-Puig, Antonio, Steen, Vidar M., López, Miguel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113797/
https://ncbi.nlm.nih.gov/pubmed/21695181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020571
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