Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumor heterogeneity (ITH) and temporal clonal evolutionary processes. To address this, we performed multiregion whole-exome sequencing on 51 tumor regions from 13 ESCCs, and mu...

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Bibliografiska uppgifter
I publikationen:Nat Genet
Huvudupphovsmän: Hao, Jia-Jie, Lin, De-Chen, Dinh, Huy Q., Mayakonda, Anand, Jiang, Yan-Yi, Chang, Chen, Jiang, Ye, Lu, Chen-Chen, Shi, Zhi-Zhou, Xu, Xin, Zhang, Yu, Cai, Yan, Wang, Jin-Wu, Zhan, Qi-Min, Wei, Wen-Qiang, Berman, Benjamin P., Wang, Ming-Rong, Koeffler, H. Phillip
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127772/
https://ncbi.nlm.nih.gov/pubmed/27749841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3683
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