Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumor heterogeneity (ITH) and temporal clonal evolutionary processes. To address this, we performed multiregion whole-exome sequencing on 51 tumor regions from 13 ESCCs, and mu...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Hao, Jia-Jie, Lin, De-Chen, Dinh, Huy Q., Mayakonda, Anand, Jiang, Yan-Yi, Chang, Chen, Jiang, Ye, Lu, Chen-Chen, Shi, Zhi-Zhou, Xu, Xin, Zhang, Yu, Cai, Yan, Wang, Jin-Wu, Zhan, Qi-Min, Wei, Wen-Qiang, Berman, Benjamin P., Wang, Ming-Rong, Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127772/
https://ncbi.nlm.nih.gov/pubmed/27749841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3683
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