Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumor heterogeneity (ITH) and temporal clonal evolutionary processes. To address this, we performed multiregion whole-exome sequencing on 51 tumor regions from 13 ESCCs, and mu...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Genet
Päätekijät: Hao, Jia-Jie, Lin, De-Chen, Dinh, Huy Q., Mayakonda, Anand, Jiang, Yan-Yi, Chang, Chen, Jiang, Ye, Lu, Chen-Chen, Shi, Zhi-Zhou, Xu, Xin, Zhang, Yu, Cai, Yan, Wang, Jin-Wu, Zhan, Qi-Min, Wei, Wen-Qiang, Berman, Benjamin P., Wang, Ming-Rong, Koeffler, H. Phillip
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127772/
https://ncbi.nlm.nih.gov/pubmed/27749841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3683
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