Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is lethal cancer whose primary tumor is characterized by dense composition of cancer cells, stromal cells and extracellular matrix (ECM) composed largely of collagen. Within the PDAC tumor microenvironment, activated pancreatic stellate cells (PSC) ar...

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發表在:Clin Cancer Res
Main Authors: Kang, Ya’an, Roife, David, Lee, Yeonju, Lv, Hailong, Suzuki, Rei, Ling, Jianhua, Rios Perez, Mayrim V., Li, Xinqun, Dai, BingBing, Pratt, Michael, Truty, Mark J., Chatterjee, Deyali, Wang, Huamin, Thomas, Ryan M., Wang, Yu, Koay, Eugene J, Chiao, Paul J., Katz, Matthew H., Fleming, Jason B.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127652/
https://ncbi.nlm.nih.gov/pubmed/27126993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2780
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