PTPN22 inhibition resets defective human central B cell tolerance

The 1858T protein tyrosine phosphatase nonreceptor type 22 (PTPN22 T) allele is one of the main risk factors associated with many autoimmune diseases and correlates with a defective removal of developing autoreactive B cells in humans. To determine whether inhibiting PTPN22 favors the elimination of...

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Udgivet i:Sci Immunol
Main Authors: Schickel, Jean-Nicolas, Kuhny, Marcel, Baldo, Alessia, Bannock, Jason M., Massad, Christopher, Wang, Haowei, Katz, Nathan, Oe, Tyler, Menard, Laurence, Soulas-Sprauel, Pauline, Strowig, Till, Flavell, Richard, Meffre, Eric
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127630/
https://ncbi.nlm.nih.gov/pubmed/27917411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf7153
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