PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis

PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of rheumatoid arthritis among non-HLA genetic variati...

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Detalhes bibliográficos
Main Authors: Chang, Hui-Hsin, Tai, Tzong-Shyuan, Lu, Bing, Iannaccone, Christine, Cernadas, Manuela, Weinblatt, Michael, Shadick, Nancy, Miaw, Shi-Chuen, Ho, I-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299735/
https://ncbi.nlm.nih.gov/pubmed/22427951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033067
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