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Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

Cyclin-dependent kinase 2 (CDK2) has been reported to be essential for cell proliferation in several human tumours and it has been suggested as an appropriate target to be considered in order to enhance the efficacy of treatment regimens based on the use of DNA damaging drugs. We evaluated the clini...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Vella, Serena, Tavanti, Elisa, Hattinger, Claudia Maria, Fanelli, Marilù, Versteeg, Rogier, Koster, Jan, Picci, Piero, Serra, Massimo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127503/
https://ncbi.nlm.nih.gov/pubmed/27898692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166233
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