Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

Cyclin-dependent kinase 2 (CDK2) has been reported to be essential for cell proliferation in several human tumours and it has been suggested as an appropriate target to be considered in order to enhance the efficacy of treatment regimens based on the use of DNA damaging drugs. We evaluated the clini...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Vella, Serena, Tavanti, Elisa, Hattinger, Claudia Maria, Fanelli, Marilù, Versteeg, Rogier, Koster, Jan, Picci, Piero, Serra, Massimo
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127503/
https://ncbi.nlm.nih.gov/pubmed/27898692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166233
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