Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

BACKGROUND: Aurora kinases are key regulators of cell cycle and represent new promising therapeutic targets in several human tumours. METHODS: Biological relevance of Aurora kinase-A and -B was assessed on osteosarcoma clinical samples and by silencing these genes with specific siRNA in three human...

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Autors principals: Tavanti, E, Sero, V, Vella, S, Fanelli, M, Michelacci, F, Landuzzi, L, Magagnoli, G, Versteeg, R, Picci, P, Hattinger, C M, Serra, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833226/
https://ncbi.nlm.nih.gov/pubmed/24129234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.643
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