Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM

The regulated recruitment of Cdc45 and GINS is key to activating the eukaryotic MCM(2-7) replicative helicase. We demonstrate that the homohexameric archaeal MCM helicase associates with orthologs of GINS and Cdc45 in vivo and in vitro. Association of these factors with MCM robustly stimulates the M...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Xu, Yuli, Gristwood, Tamzin, Hodgson, Ben, Trinidad, Jonathan C., Albers, Sonja-Verena, Bell, Stephen D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127375/
https://ncbi.nlm.nih.gov/pubmed/27821767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613825113
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