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Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM
The regulated recruitment of Cdc45 and GINS is key to activating the eukaryotic MCM(2-7) replicative helicase. We demonstrate that the homohexameric archaeal MCM helicase associates with orthologs of GINS and Cdc45 in vivo and in vitro. Association of these factors with MCM robustly stimulates the M...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5127375/ https://ncbi.nlm.nih.gov/pubmed/27821767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613825113 |
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