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Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel
Cytoplasmic calcium (Ca(2+)) activates the bestrophin anion channel, allowing chloride ions to flow down their electrochemical gradient. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Previously, we determined an X-ray structure of chicken BEST1 that revealed the architectur...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5127342/ https://ncbi.nlm.nih.gov/pubmed/27821745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614688113 |
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