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An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1
Bestrophin proteins are calcium (Ca(2+))-activated chloride channels. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Whole-cell recordings show that ionic currents through BEST1 run down over time, but it is unclear whether this behavior is intrinsic to the channel or the re...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219684/ https://ncbi.nlm.nih.gov/pubmed/30237227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812190 |
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