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Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel

Cytoplasmic calcium (Ca(2+)) activates the bestrophin anion channel, allowing chloride ions to flow down their electrochemical gradient. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Previously, we determined an X-ray structure of chicken BEST1 that revealed the architectur...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vaisey, George, Miller, Alexandria N., Long, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127342/
https://ncbi.nlm.nih.gov/pubmed/27821745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614688113
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