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Structure and Selectivity in Bestrophin Ion Channels
Human bestrophin 1 (hBest1) is a calcium-activated chloride channel from the retinal pigment epithelium, where it can suffer mutations associated with vitelliform macular degeneration, or Best disease. We describe the structure of a bacterial homolog (KpBest) of hBest1 and functional characterizatio...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4341822/ https://ncbi.nlm.nih.gov/pubmed/25324390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259723 |
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