HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. The high density of glycosylation on the viral spike limits enzymatic processing, resulting in numerous underprocessed oligomannose-type glycans. This extensive glycosylation not only shields conserved re...

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Pubblicato in:J Virol
Autori principali: Coss, Karen P., Vasiljevic, Snezana, Pritchard, Laura K., Krumm, Stefanie A., Glaze, Molly, Madzorera, Sharon, Moore, Penny L., Crispin, Max, Doores, Katie J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126371/
https://ncbi.nlm.nih.gov/pubmed/27707925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01542-16
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