Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance

Broadly neutralizing antibodies have been isolated that bind the glycan shield of the HIV-1 envelope spike. One such antibody, PGT135, contacts the intrinsic mannose patch of gp120 at the Asn332, Asn392, and Asn386 glycosylation sites. Here, site-specific glycosylation analysis of recombinant gp120...

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Vydáno v:J Virol
Hlavní autoři: Pritchard, Laura K., Spencer, Daniel I. R., Royle, Louise, Vasiljevic, Snezana, Krumm, Stefanie A., Doores, Katie J., Crispin, Max
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468474/
https://ncbi.nlm.nih.gov/pubmed/25878100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00230-15
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