A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation

Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive targets for drug discovery. Eukaryotic acetyl-CoA carboxylases are 250 kDa single-chain, multi-domain enzymes and function as dimers and higher oligomers. Their catalytic activity is tightly regulated by phosphorylation and...

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Veröffentlicht in:Cell Discov
Hauptverfasser: Wei, Jia, Zhang, Yixiao, Yu, Tai-Yuan, Sadre-Bazzaz, Kianoush, Rudolph, Michael J, Amodeo, Gabriele A, Symington, Lorraine S, Walz, Thomas, Tong, Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126230/
https://ncbi.nlm.nih.gov/pubmed/27990296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.44
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