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Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer

Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer and other diseases(1–6). Saccharomyces cerevisiae ACC (ScACC) is crucial for the production of very-long-chain fatty acids and the maintenance of the nuclea...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Wei, Jia, Tong, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838907/
https://ncbi.nlm.nih.gov/pubmed/26458104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15375
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