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Histone Deacetylase 5 is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repressing Pro-angiogenic Factors
OBJECTIVE: Vascular dysfunction represents a disease initiating event in scleroderma (SSc). Recent data suggest that epigenetic dysregulation impairs normal angiogenesis and can result in abnormal blood vessel growth patterns. Histone deacetylases (HDACs) control endothelial cell (EC) proliferation...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5125850/ https://ncbi.nlm.nih.gov/pubmed/27482699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39828 |
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