Activation of the thromboxane A2 receptor by 8-isoprostane inhibits the pro-angiogenic effect of vascular endothelial growth factor in scleroderma

The pathogenesis of scleroderma (SSc) includes components of autoimmunity, vascular dysfunction, and accumulation of extracellular matrix. 8-isoprostane, an oxidized lipid created by oxidative stress, activates the thromboxane A2 receptor (TXAR) and ROCK pathway. In this study we determined whether...

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Publicat a:J Invest Dermatol
Autors principals: Tsou, Pei-Suen, Amin, M. Asif, Campbell, Phil, Zakhem, George, Balogh, Beatrix, Edhayan, Gautam, Ohara, Ray A., Schiopu, Elena, Khanna, Dinesh, Koch, Alisa E., Fox, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648660/
https://ncbi.nlm.nih.gov/pubmed/26288351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.323
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