RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and humans, resulting in secondary ischemic complications and high mortality. We show that, in ApoE(−/−) mice with coronary ligation, increased sympathetic tone up-regulates not only hematopoietic leukocyte product...

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Pubblicato in:Sci Transl Med
Autori principali: Sager, Hendrik B., Dutta, Partha, Dahlman, James E., Hulsmans, Maarten, Courties, Gabriel, Sun, Yuan, Heidt, Timo, Vinegoni, Claudio, Borodovsky, Anna, Fitzgerald, Kevin, Wojtkiewicz, Gregory R., Iwamoto, Yoshiko, Tricot, Benoit, Khan, Omar F., Kauffman, Kevin J., Xing, Yiping, Shaw, Taylor E., Libby, Peter, Langer, Robert, Weissleder, Ralph, Swirski, Filip K., Anderson, Daniel G., Nahrendorf, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125383/
https://ncbi.nlm.nih.gov/pubmed/27280687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf1435
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