RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and humans, resulting in secondary ischemic complications and high mortality. We show that, in ApoE(−/−) mice with coronary ligation, increased sympathetic tone up-regulates not only hematopoietic leukocyte product...

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發表在:Sci Transl Med
Main Authors: Sager, Hendrik B., Dutta, Partha, Dahlman, James E., Hulsmans, Maarten, Courties, Gabriel, Sun, Yuan, Heidt, Timo, Vinegoni, Claudio, Borodovsky, Anna, Fitzgerald, Kevin, Wojtkiewicz, Gregory R., Iwamoto, Yoshiko, Tricot, Benoit, Khan, Omar F., Kauffman, Kevin J., Xing, Yiping, Shaw, Taylor E., Libby, Peter, Langer, Robert, Weissleder, Ralph, Swirski, Filip K., Anderson, Daniel G., Nahrendorf, Matthias
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125383/
https://ncbi.nlm.nih.gov/pubmed/27280687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf1435
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