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Effects of p21-activated kinase 1 inhibition on 11q13 amplified ovarian cancer cells
p21-activated kinases (PAKs) are Cdc42/Rac–activated serine-threonine protein kinases that regulate of several key cancer-relevant signaling pathways, such as the Mek/Erk, PI3K/Akt, and Wnt/b-catenin signaling pathways. Pak1 is frequently overexpressed and/or hyperactivated in different human cancer...
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| Publié dans: | Oncogene |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5125076/ https://ncbi.nlm.nih.gov/pubmed/26257058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.278 |
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