Effects of p21-activated kinase 1 inhibition on 11q13 amplified ovarian cancer cells

p21-activated kinases (PAKs) are Cdc42/Rac–activated serine-threonine protein kinases that regulate of several key cancer-relevant signaling pathways, such as the Mek/Erk, PI3K/Akt, and Wnt/b-catenin signaling pathways. Pak1 is frequently overexpressed and/or hyperactivated in different human cancer...

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Bibliographic Details
Published in:Oncogene
Main Authors: Prudnikova, Tatiana Y., Villamar-Cruz, Olga, Rawat, Sonali J., Cai, Kathy Q., Chernoff, Jonathan
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125076/
https://ncbi.nlm.nih.gov/pubmed/26257058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.278
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