6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand

The 6β-N-heterocyclic naltrexamine derivative, NAP, has been demonstrated to be a peripherally selective mu opioid receptor modulator. To further improve peripheral selectivity of this highly potent ligand, its pyridal ring was quaterinized with benzyl bromide to produce BNAP. In radioligand binding...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Williams, Dwight A., Zheng, Yi, David, Bethany G., Yuan, Yunyun, Zaidi, Saheem A., Stevens, David L., Scoggins, Krista L., Selley, Dana E., Dewey, William L., Akbarali, Hamid I., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125022/
https://ncbi.nlm.nih.gov/pubmed/27269866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00075
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