Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective Antagonists

Opioid receptor selective antagonists are important pharmacological probes in opioid receptor structural characterization and opioid agonist functional study. Thus far, a nonpeptidyl, highly selective and reversible μ opioid receptor (MOR) antagonist is unavailable. On the basis of our modeling stud...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Guo, Aschenbach, Lindsey C., Chen, Jianyang, Cassidy, Michael P., Stevens, David L., Gabra, Bichoy H., Selley, Dana E., Dewey, William L., Westkaemper, Richard B., Zhang, Yan
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880636/
https://ncbi.nlm.nih.gov/pubmed/19199782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801272c
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