Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

Although commonly used to control a variety of inflammatory diseases, the mechanism of action of a low dose of methotrexate remains a mystery. Methotrexate accumulates intracellularly where it may interfere with purine metabolism. Therefore, we determined whether a 48-hr pretreatment with methotrexa...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cronstein, B N, Eberle, M A, Gruber, H E, Levin, R I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2441
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