Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

Although commonly used to control a variety of inflammatory diseases, the mechanism of action of a low dose of methotrexate remains a mystery. Methotrexate accumulates intracellularly where it may interfere with purine metabolism. Therefore, we determined whether a 48-hr pretreatment with methotrexa...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Cronstein, B N, Eberle, M A, Gruber, H E, Levin, R I
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2441
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