Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.
Although commonly used to control a variety of inflammatory diseases, the mechanism of action of a low dose of methotrexate remains a mystery. Methotrexate accumulates intracellularly where it may interfere with purine metabolism. Therefore, we determined whether a 48-hr pretreatment with methotrexa...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1991
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2441 |
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