Stimulation of Slack K(+) channels alters mass at the plasma membrane by triggering dissociation of a phosphatase-regulatory complex

Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylation of a Slack C-terminal residue by protein kinas...

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Udgivet i:Cell Rep
Main Authors: Fleming, Matthew R., Brown, Maile R., Kronengold, Jack, Zhang, Yalan, Jenkins, David P., Barcia, Gulia, Nabbout, Rima, Bausch, Anne E., Ruth, Peter, Lukowski, Robert, Navaratnam, Dhasakumar S., Kaczmarek, Leonard K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123741/
https://ncbi.nlm.nih.gov/pubmed/27545877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.024
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