Human Slack potassium channel mutations increase positive cooperativity between individual channels

Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation or voltage-dependence. We examined nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel that give rise to three distinct forms of epilepsy. All produced many f...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kim, Grace E., Kronengold, Jack, Barcia, Giulia, Quraishi, Imran H., Martin, Hilary C., Blair, Edward, Taylor, Jenny C., Dulac, Olivier, Colleaux, Laurence, Nabbout, Rima, Kaczmarek, Leonard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294418/
https://ncbi.nlm.nih.gov/pubmed/25482562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.11.015
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