Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets....

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Publicado en:Nat Commun
Main Authors: Brereton, Melissa F., Rohm, Maria, Shimomura, Kenju, Holland, Christian, Tornovsky-Babeay, Sharona, Dadon, Daniela, Iberl, Michaela, Chibalina, Margarita V., Lee, Sheena, Glaser, Benjamin, Dor, Yuval, Rorsman, Patrik, Clark, Anne, Ashcroft, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123088/
https://ncbi.nlm.nih.gov/pubmed/27882918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13496
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